Electron Microscopy Sample Preparation: A Critical Step for High-Resolution Imaging
Electron microscopy (EM) is a powerful imaging technique used to visualize structures at the nanometer and even atomic scale. Unlike light microscopy, EM uses electron beams instead of visible light, which allows for significantly higher resolution. However, achieving high-quality images depends heavily on proper sample preparation, which is often a complex and meticulous process.
Importance of Sample Preparation
Samples for electron microscopy must withstand high vacuum conditions and the electron beam without degrading or moving. Proper preparation preserves the sample’s structure, provides adequate contrast, and minimizes artifacts, enabling accurate imaging and analysis.
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